![]() ![]() Boron neutron capture therapy (BNCT) is based on the ability of the boron-10 ( 10B) isotope to capture epithermal neutrons, as a result of which the isotope becomes unstable and decays into kinetically active elements that destroy cells where the nuclear reaction has occurred. ![]() The boron-carrying compounds-L-para-boronophenylalanine (BPA) and sodium mercaptoundecahydro-closo-dodecaborate (BSH)-have low toxicity and, today, are the only representatives of such compounds approved for clinical trials. For the effectiveness and safety of BNCT, a low boron content in normal tissues and substantially higher content in tumor tissue are required. This study evaluated the boron concentration in intracranial grafts of human glioma U87MG cells and normal tissues of the brain and other organs of mice at 1, 2.5 and 5 h after administration of the boron-carrying compounds. A detailed statistical analysis of the boron biodistribution dynamics was performed to find a ‘window of opportunity’ for BNCT. The data demonstrate variations in boron accumulation in different tissues depending on the compound used, as well as significant inter-animal variation. The protocol of administration of BPA and BSH compounds used did not allow achieving the parameters necessary for the successful course of BNCT in a glioma orthotopic xenograft mouse model. Compute answers using Wolframs breakthrough technology & knowledgebase, relied on by millions of students & professionals. Therapy for malignant tumors in the human brain is rather challenging. Natural Language Math Input Extended Keyboard Examples Upload Random. Despite considerable efforts to develop new drugs and treatments, patients’ mean overall survival has increased by only three months (from 12 to 15 months). Their invasive nature and location in vital regions of the human brain make these types of tumors difficult for surgery however, adjuvant therapy does not provide the desired results. Therefore, the elaboration of targeted radiotherapy methods is a promising approach for brain tumor therapy. ![]() One such treatment option may be boron neutron capture therapy (BNCT).īNCT exploits the ability of the isotope 10B to capture thermal neutrons and produce 478 keV γ rays, 4He particles and 7Li recoil ions, the latter two have high-linear energy transfer properties and a high biological effectiveness relative to photons. The range of these particles in tissue is restricted from 4 to 8 µm, thus limiting their effects to one cell diameter. In a bid to raise awareness of internet freedom, Internet Archive created a timeline from 2022 to 2046 alongside the Wayforward Machine, with several predictions. ![]()
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